用光控制药物活动

在新的出版物中,波利纳·奥迪瓦教授和俄亥俄州研究助理教授詹姆斯弗兰克教授联合领导的团队介绍了一种微纤维技术来提供和激活可以通过暴露于光线诱导其受体的雷竞技下载链接 官网app药物。

为了使用光来控制药物活性,光和药物必须同时向靶细胞递送,当靶在体内深处时,这可能是困难的。“A significant barrier in applying light-controllable drugs to modulate neural circuits in living animals is the lack of hardware which enables simultaneous delivery of both light and drugs to the target brain area,” says Frank, who was previously a postdoc in Anikeeva’s Bioelectronics group within the Department of Materials Science and Engineering at MIT. “Our work offers an integrated approach for on-demand delivery of light and drugs through a single fiber."

纤维含有流体通道和光波导,并且由许多不同材料层组成,这些不同材料融合在一起以提供柔韧性和强度。纤维的原始形式在宏观上构造,然后加热和拉动(称为热绘图的过程)变长,但直径越小70倍。通过这种方法,可以从原始模板以微米的横截面刻度从原始模板产生数百米的小型化光纤,从而最大限度地减少组织损伤。